In the study, many of the participants on Pycnogenol reduced their dosage of high-blood-pressure medication (nifedipine) [37]. Inhibits platelet aggregation like low-dose aspirin. but is for informational and educational purposes alone. Eliminate blood clots. This condition is due to the pooling of blood in the veins of the lower legs. Pine bark extract comes from the inner bark of the Pinus pinaster tree, most commonly found in Europe. Pycnogenol is a substance taken from the pine bark of trees found in the southwest region of France. Pycnogenol was gradually increased to 120 mg/day over this time period, while the l-arginine was maintained at 1.7 g/day throughout. Interactions. Chestnut seed extract did not do as well. As a skin powder, however, you can use it safely for up to six weeks. Some people who have asthma have higher levels of leukotrienes in their blood. Prunes and prune juice have many health benefits. As I mentioned, pine bark extract is superior when it comes to antioxidants. No side effects were noted, unlike its synthetic counterpart. Pycnogenol treatment resulted in more normal-looking sperm. Speak with your doctor before supplementing. SelfDecode is a personalized health report service, Start with a low dose so you can be sure it doesnt cause any side effects. Ac., CYT, 12 Benefits of Ginkgo Biloba (Plus Side Effects & Dosage), Tongkat Ali (Eurycoma longifolia): Everything You Need to Know, reduce blood sugar levels in people with diabetes, are within two weeks of a scheduled surgery, medications, herbs, and supplements that affect the blood or clotting. Headaches. painful urination. It can also be found as creams, lotions or ointments, typically containing 0.5 percent to 2 percent pine bark extract. One study found that Pycnogenol may reduce the activity of the inflammatory enzymes COX1 and COX2, similar to how NSAID drugs work. There is currently insufficient evidence to determine what a safe and effective dose of lysine is for specific conditions. It also may enhance swimming, biking, and running scores in professional athletes preparing for a triathlon (at 150 mg/day). Almost 400 years later, Dr. Jacques Masquelier from France came across Cartiers account and started to look for the active ingredients from the bark of the tree. A Pycnogenol combination product (with l-arginine, alpha lipoic acid, B vitamins, and vitamin K2) may help protect the blood vessels and reduce high homocysteine levels, according to a trial of 25 people [39]. DOI: Marini A, et al. Pycnogenol pine bark extracts contain a unique blend of flavonoids whose antioxidant action is over is 50 times more powerful than vitamin E, 20 times more powerful than vitamin C and 16 times more active than grapeseed extracts. Another study found this supplement can even halt progression of vision . The outcome showed significant healing when compared to those subjects who were not given any drug or remedy, concluding that Pycnogenol may be an effective remedy for healing of surgery-related lesions. From diabetes and sexual function to sports performance and beautiful skin, pine bark extract may be worth exploring to provide results youre looking to achieve. They also had normalized fasting glucose levels and blood pressure, which can also reduce a persons risk of heart problems. Pine bark extract offers some amazing benefits since its so high in powerful antioxidants. Pycnogenol (100 mg/day) may reduce hay fever symptoms, according to a clinical trial of 39 people. (4). If you knew you could resolve your erectile dysfunction and, therefore, naturally remedy impotence issues, wouldnt you? For example, Enzogenol is an extract from a pine that grows in California and Mexico (Pinus radiata) that may have cognitive-enhancing effects. In addition to OPC, grape seed extract contains linoleic acid, flavonoids and phenolic procyanidins that help protect and strengthen capillaries, blood vessels, veins and arteries, which can then improve blood circulation. Vertigo. Pycnogenol is the registered trademark name for a French formula. Also, be sure to talk with your doctor first if you have an underlying medical condition or take other medications. Pycnogenol has given indications that it might be able to benefit heart and artery health, to include reducing high blood pressure. Pycnogenol may help reduce symptoms of melasma, a form of hyperpigmentation, possibly because it protects against UV rays. (5). Pine bark extract can be found in liquid, tablet or capsule form containing 85 percent to 90 percent OPCs. However, healthy people are not immune and can also develop mild infections, in particular after being in improperly chlorinated hot tubs or swimming pools. Read More: Health Benefits of Peanut Butter. Thirty patients with diabetic ulcers were treated with 150 mg Pycnogenol daily for four weeks and another group of 30 comparable patients received no treatment. In one study, 10 patients were treated with placebo and 30 patients were treated with Pycnogenol (100 mg twice or three times daily for two months). The effects of the pine bark extract showed significant lower levels of blood glucose and improved endothelial function when compared to placebo, concluding that supplementation of Pycnogenol for treating conventional diabetes may be beneficial. (2015). Not bad. All rights reserved. But what are its health benefits? 4 Items . Pycnogenol was featured on The Dr. Oz Show in January 2013, . Pine bark extract may be the perfect treatment since its an antioxidant dynamo. Arginine is a non-essential amino acid because most humans can make it in their bodies. Debra Rose Wilson, PhD, MSN, RN, IBCLC, AHN-BC, CHT. Risks. 1 Anti-Aging Beverage, An surprisingstudy found that pine bark extract was far better than aspirin at inhibiting smoking-induced clotting, using lower amounts without the bleeding often found when using aspirin. It also provides powerful antioxidant protection and helps inhibit inflammatory factors to support. However, this was a relatively small study, so larger ones are needed to fully understand pine bark extracts role in these findings. Some risks associated with Pycnogenol include:, Pycnogenol and other maritime tree barks have not been studied as extensively as traditional medicine. The U.S. Food and Drug Administration (FDA) does regulate dietary supplements; however, it treats them like foods rather than medications. Moreover, Pycnogenol treatment led to an increase in sperm count and testosterone levels with lowering of blood pressure and cholesterol levels. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox. When pycnogenol cream was added to oral supplements in a small study of 18 people with vein ulcers, it helped ulcers heal more quickly [26]. Our website services, content, and products are for informational purposes only. Pycnogenol is thought to be an antioxidant that helps protect cells from damage. Known for its antioxidant properties, Pycnogenol offers a wide range of potential health benefits. Studies on human subjects have reported few side effects - even . Align your health hacks with your genes for optimal health & cognitive function. Natural Factors Pycnogenol 100mg 30 Veggie Caps. Disease of the retina in the eye. Here are 12 benefits of ginkgo biloba. Researchers suggest that it may have stronger benefits than elastic compression stockings. High-dose Pycnogenol (360 mg/day) for 4 weeks had the same LDL-lowering benefits in another study of 40 people [32, 56]. He later extracted proanthocyanidins from the European coastal pine tree, which he named Pycnogenol.. Some pycnogenol supplements are mixed with other antioxidants, such as vitamin C. Pine bark extracts other than pycnogenol are also sold. Theres evidence that Pycnogenol may be a promising nootropic for various groups of people, including middle-aged professionals, students, and people with mild cognitive decline like brain fog. There havent been enough studies yet to change practice protocols for treating children. In the placebo group, the retinopathy worsened; whereas, in the Pycnogenol-treated group, there was no deterioration. In another study, 45 men with ED were given 1.7 grams of L-arginine a day during the first month, 40 mg Pycnogenol twice daily during the second month, and the dose increased to three 40-mg Pycnogenol doses daily during the third month. According to researchers, it may help prevent the rise in free radicals typically seen after exercise, which could cause muscle fatigue and damage [9]. DIM and other plant indoles are found in . Blood pressure is an important measure of how much blood is pumping from your heart to the rest of your body. Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. A combination product with Pycnogenol (Lady Prelox) improved sexual function in a clinical trial of 83 healthy postmenopausal women after 8 weeks. The specific tree from which the bark is extracted is called a maritime pine. ", Panminerva Medica: "Supplementation with Pycnogenol improves signs and symptoms of menopausal transition.". It also slightly decreased blood pressure and increased testosterone [67]. Pycnogenol treatment led to significantly better improvement in the lung function and asthma symptoms. Pycnogenol is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins . Discover what the research says about elimination diets, foods to eat, and more. is a clickable link to peer-reviewed scientific studies. Dr. Drew explains the benefits of probiotics for the gut microbiome and talks about the rise of leaky gut, and Dr. Steve shares how emotional stress can have real physical effects on the heart. Research indicates that Pycnogenol provides an increase in endurance performance of trained athletes. Twenty-one patients were given Pycnogenol at 150 mg daily and 18 patients received no treatment for a period of eight weeks. Upset stomach. You can learn more about how we ensure our content is accurate and current by reading our. L-arginine is more effective when paired with L-citrulline or pycnogenol to combat erectile dysfunction and improve exercise performance. Make sure to seek out the advice of your physician prior to using pine bark extract or the branded name, Pycnogenol. ( 1) 2. The goal of this study was to evaluate if Pycnogenol could prevent deep venous thrombosis (DVT) and superficial vein thrombosis (SVT) in eight-hour flights in 196 subjects at risk of these conditions. . 2005 - 2023 WebMD LLC. Pycnogenol (150 mg/day) reduced pain in a study of 100 people with osteoarthritis after 3 months. Research into Pycnogenol has revealed some promising results in over 30 health conditions. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. Information is shared for educational purposes only. Plus, it reduced total and LDL (bad) cholesterol. In a good-quality study, 77 patients with osteoarthritis were treated with 100 mg of Pycnogenol daily and 79 patients were treated with placebo for three months. Researchers suggest that it may epigenetically turn off genes responsible for joint damage (ADAMTS) as well as reduce inflammation enzymes (MMP3) and cytokines (IL 1-beta) [47, 48]. In one clinical trial of 156 osteoarthritis patients, pycnogenol reduced pain, stiffness, swelling, and improved joint function after 3 months. Pycnogenol, an extract of French maritime pine bark, helps the body fight normal aging by supporting vascular health and healthy circulation. Learn more. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. However, these studies appear to be methodologically sound and reliable, with no blatant errors in the study design and data collection. $47.99. While it may seem intimidating at first, counting macros is a common Erythritol is now one of the most popular natural zero-calorie sweeteners available. Pycnogenol (100 mg/day) given to 44 older healthy people with high oxidative stress improved cognitive function, attention, mental performance, and reduced oxidative stress after 12 months [21]. By clicking Subscribe, I agree to the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Becoming a Vegetarian: Foods to Choose From. Another clinical trial of 76 people with allergic asthma also suggests that Pycnogenol may reduce IgE antibodies and asthma symptoms [18, 16]. A review was conducted of French maritimepine bark extract, specifically using the nutritional supplement Pycnogenol. (1, 2). Blazs G, et al. In this study, 155 peri-menopausal women were enrolled in a double-blind, placebo-controlled study. A randomized, double-blind, placebo-controlled study of 60 patients aged six to 18 years old, was conducted over three months during which patients were randomly assigned to receive either Pycnogenol or placebo. Prenatal nutrition can be confusing. Symptoms of menopausal syndrome, also known as climacteric syndrome, include: hot flashes; chills; headache; and depression. We take a look at what the science actually says. Memorial Sloan-Kettering Cancer Center web site: "About Herbs: Pine Bark Extract. In patients with chronic venous insufficiency, the number of muscle cramps decreased from 6.3 to 2.6; in athletes from 8.6 to 2.4. A study with four groups of 30 patients each were studied: (1) systemic Pycnogenol and local application; (2) local Pycnogenol only; (3) oral Pycnogenol and (4) medications only (control). The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. They include: We need more research to know for sure if pycnogenol helps treat these conditions. Top 9 Natural Allergy Relief Home Remedies - Dr. Axe 1 week ago from draxe.com Eat an Anti-Inflammatory, Alkaline Diet. The results of a 2013 animal study suggest that pine bark extract may help to reduce damage to nerve cells following a traumatic brain injury. Two studies illustrate the possibilities: One was a randomized, double-blind, placebo-controlled, crossover study in which 26 asthmatic patients were given either a maximum of 200 mg a day of Pycnogenol or placebo for the first period of four weeks and then crossed over to the alternate treatment for the next four weeks. Studies have found that when taken along with an inhaler, Pycnogenol can reduce leukotrienes, helping to relieve lung inflammation and limit frequency of inhaler use., Many people develop osteoarthritis as they age. Researchers from the study suggest that low Pycnogenol dosage and short study duration may explain the lack of benefits [44]. Most anal fissures heal with home treatment after a few days or weeks. Ana spent years working with patients who suffer from various mental health issues and chronic health problems. Quality and active ingredients in supplements may vary widely from maker to maker. In a study of 100 healthy women mostly in their early 40s with mild sexual dysfunction, a combination product with Pycnogenol (Lady Prelox) improved sexual function over 8 weeks [74]. While OPCs found in this extract are mostly known for their antioxidant-producing benefits, these amazing compounds exude antibacterial, antiviral, anticarcinogenic, anti-aging, anti-inflammatory and anti-allergic properties. There's good evidence that pycnogenol helps with eye damage caused by diabetes. In the Pycnogenol-treated group, blood sugar levels were significantly lowered as compared to those not on Pycnogenol. In another study, Pycnogenol increased glutathione levels and total antioxidants after a month in children with ADHD [42, 43]. Add to Cart. For people who have symptoms that are more severe, traditional medicine is probably more effective. Pycnogenol in metabolic syndrome and related disorders [Abstract]. Pycnogenol is the leading ingredient in Isotonix OPC-3, Market America's best-. The supplement significantly reduced hot flashes, night sweats, mood swings, irregular periods, loss of libido, and vaginal dryness. Are there any risks to taking it? If you are taking blood thinners, do not take pine bark extract or Pycnogenol unless approved by your doctor. editor, The Gale Encyclopedia of Alternative Medicine, third edition, 2009. Rating: 100%. - Please read carefully and implement principles included in the Health Recovery Plan. According to a study in 59 cancer patients, Pycnogenol (150 mg/day) may reduce side effects associated with radiation or chemotherapy, including mouth soreness and ulcers, mouth and eye dryness, nausea, vomiting, diarrhea and weight loss [78]. The standard dose appears to be 100-200 mg/day. Masquelier was easily able to create a pine bark extract from materials that were otherwise known as waste. Erythritol: Is This Healthy Sweetener the Real Deal? A deficiency can cause issues like anemia, stunted growth, heart problems and neural tube defects. Jonathan Ritter, PharmD, PhD (Pharmacology), Small molecule antioxidants (phenolic acids, catechin, and taxifolin) are quickly absorbed and begin to act in the body within 30 min, The remaining more complex antioxidants (long chains of procyanidins) reach the gut, where your, The microbiome-produced active compounds appear in blood 6 h later and remain for at least 14 h, Pycnogenol is standardized to contain 70 5% procyanidins, which should be on the label, Pycnogenol standardization doesnt determine other major active compounds, which can vary. In a clinical trial of 40 men with erectile dysfunction, 92.5% of the men on this combination regained normal erections after 3 months. While pine bark extract is thought to be safe for children, they should only take it for a few weeks at a time. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. Regardless of what youre using it for, its best to start with the lowest possible dose. (2013). In a good-quality study, 24 adults aged 24 to 53 years old with attention deficit hyperactivity disorder (ADHD) were given Pycnogenol, placebo, or the standard drug for three weeks. Blood clots form as a result of platelet aggregation, which is the platelets in the blood clumping together. Chemistry. The researchers concluded that pine bark extract may increase production of hyaluronic acid and collagen, which are both found in many popular antiaging products. Diabetes-associated small blood vessel changes is the leading cause of diabetic ulcers. Instead, use plain water to wipe yourself and then dry your bottom afterward. While these results are promising, there isnt enough research to fully understand the effect of antioxidant levels on ADHD symptoms. Consider pine bark extract through a conversation with your physician or a functional medicine doctor. Lets begin with asthma. Staves Off Infections. Furthermore, when CHS was suppressed by 71% with exogenous treatment with cis-urocanic acid, the putative epidermal mediator of photoimmunosuppression, 0.2% Pycnogenol lotion reduced the immunosuppression to 18%. You can find out your systolic blood pressure by looking at the top number of a blood pressure test. Improve cardiovascular health. Its likely that muscle recovery time improved as well due to the high antioxidants pine bark extract contains. Once youre sure that you dont have any negative reactions, you may be able to increase your dosage according to the label. Enzogenol, a slightly different pine bark extract, may help improve brain function after mild concussions. In a good-quality study, 100 patients with osteoarthritis of the knee were treated for three months either with 150 mg of Pycnogenol a day or placebo. If you take any medications regularly, talk to your doctor before you start using pycnogenol supplements. However, it is also important to see beyond the pyncogenol marketing campaign and understand the possible dangers associated with this natural supplement. A small 2017 study examined the effects of pine bark extract in treating cardiovascular risk factors associated with menopause. With time, the participants were able to handle more UV radiation without experiencing skin damage [63]. Learn about this tree-based pill and how it might be able to help you. Sign Up for the Latest Health News and Tips, Home Food and Nutrition Pycnogenol (French Maritime Pine Bark Extract): 12 Benefits According to Studies. Therefore, those who have autoimmune conditions could see their symptoms increase after taking it., Since Pycnogenol is used for so many conditions, doses can vary. (2012). However, it's always a good idea to start with a low dose so you can monitor how your body responds. Your email address will not be published. Another study in 2012 showed that Pycnogenol alone, at a dose of 75 mg/day, increased skin hydration by 8% after just 6 weeks; in women with dry skin at baseline the increase was 21%. Pine bark distill has been studied regarding its relationship to exercise performance, oxidative stress and excitement to torso that has been imposed by exercise. DOI: Chowdhury WK, et al. Because of its anti-inflammatory effects, nattokinase has been used to help with pain from arthritis, including that of rheumatoid arthritis. 5) Vein Diseases and Swelling. SelfDecode does not treat, diagnose or cure any conditions, If youre native to Oregon, you likely know all about marionberries. In a small/preliminary study of kids with asthma, pycnogenol helped improve symptoms. 5) Inflammation and Allergies. Along with the rest of the crew, he developed symptoms of vitamin-C deficiency. Pycnogenol-treated subjects experienced an improvement in all menopausal symptoms. A trial of 86 people with eye damage from diabetes found that antioxidant therapy (including pycnogenol, vitamin E, and Coenzyme Q10) may improve eye health and reduce reactive oxygen species levels [35]. 2005-2023 Healthline Media a Red Ventures Company. A clinical trial of 60 health professionals found that Pycnogenol (150 mg/day) may improve cognitive function, attention, mental performance and specific professional skills after 12 weeks. 5 6 However, evidence is conflictingother studies have shown no effect on the same measures. In some people lung inflammation is caused by leukotrienes chemicals that are released by the body after a person encounters allergens. Joe Cohen flipped the script on conventional and alternative medicine and it worked. In oneparticular study published in Research in Pharmaceutical Sciences, researchers investigated the antibacterial activity of pine bark extract essential oil on staph infections, E. coli and pseudomonas infections. A trial of 53 students found that pycnogenol may improve cognitive function, memory, attention, mood, and mental performance after 8 weeks [20]. This ensures that there is a healthy flow of blood to and from the heart. Studies have also safely used Pycnogenol in children and during pregnancy. Pycnogenol completely normalized function. These antioxidants scavenge those damaging free radicals in an effort to eliminate them, ultimately preventing disease. Pine bark extract appears to reduce the creation of free radicals, which are molecules linked to several skin conditions. Lower the risk of Alzheimer's disease. First and foremost, start eating an anti-inflammatory Local Raw Honey (Bee Pollen) Considering how good it tastes, having some raw honey Apple Cider Vinegar (ACV) You can now find high-quality apple cider vinegar in . In another study, 61 children with ADHD were given one mg per kg/day of Pycnogenol or placebo over four weeks. High levels of both of these are considered risk factors for heart disease. Procyanidins are chain-like structures consisted of catechins similar to some found in green tea (the green tea catechins that do not have 'gallate' in their names).

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