Scientists havent tested these supplements much, so theres not enough research to know if they fight osteoporosis. A generic, non-branded version of strontium ranelate, from Aristo Pharma Ltd., is still available in the U.K.[2] with a number of special warnings and precautions for its use. JAMA 12-17-2003;290(23):3115-3121. B., Gamble, G. D., and Reid, I. R. Effect of osteoporosis treatment on mortality: a meta-analysis. Clin Sci 1968;34:351-63. 2010;21(12):1993-2002. PROOF Study Group. Review of clinical studies. With a few simple measures, the application of Sr-89 causes no problems. Ann Intern Med 2007;146:580-90. Boron has been consumed for menstrual cramps and boric acid has been used vaginally for yeast infections, but evidence is limited. Available at: www.atsdr.cdc.gov/toxprofiles/tp159.pdf. View abstract. Cummings, S. R., Black, D. M., Thompson, D. E., Applegate, W. B., Barrett-Connor, E., Musliner, T. A., Palermo, L., Prineas, R., Rubin, S. M., Scott, J. C., Vogt, T., Wallace, R., Yates, A. J., and LaCroix, A. Is it even safe? 2006;3:CD005326. 2010;30(10):1341-1348. Initially Forteo was top contender (refrigeration requirement is an issue) until I came across Tymlos (refrigeration being easier to manage is one of several benefits over Forteo). Harris, S. T., Watts, N. B., Genant, H. K., McKeever, C. D., Hangartner, T., Keller, M., Chesnut, C. H., III, Brown, J., Eriksen, E. F., Hoseyni, M. S., Axelrod, D. W., and Miller, P. D. Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. 1978;49(5):269-272. Results of Russian multicenter trial]. Metastron prescribing information. N.Engl.J.Med. Baziotis N, Yakoumakis E, Zissimopoulos A, et al. View abstract. (13). Expert.Opin.Investig.Drugs 2004;13(7):857-864. View abstract. Strontium is considered to be safe in normal food amounts and as a toothpaste ingredient. In Australia and some countries in Europe, a form of strontium called strontium ranelate (Osseor Protelos) is available as a prescription medication to treat and prevent osteoporosis and bone fractures. View abstract. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. Ozgur S, Sumer H, Kocoglu G. Rickets and soil strontium. J Am Diet Assoc 1987;87:1644-50. View abstract. Periodontics. It can be found in soil and seawater as well as some foods. Esomeprazole (Nexium) is not the same medication as esomeprazole strontium, although both are used to treat similar stomach conditions. Chemical exchange between glass-ionomer restorations and residual carious dentine in permanent molars: an in vivo study. Bruyere, O., Roux, C., Detilleux, J., Slosman, D. O., Spector, T. D., Fardellone, P., Brixen, K., Devogelaer, J. P., Diaz-Curiel, M., Albanese, C., Kaufman, J. M., Pors-Nielsen, S., and Reginster, J. Y. It is not approved in the USA.[3]. Any use of this site constitutes your agreement to the Terms of Use and Privacy Policy and Conditions of Use linked below. Use strontium supplements with caution if you have kidney disease. The next big and interesting use of this alkaline earth metal was when it was used in the television production industry, specifically in the cathode ray tubes of color televisions. (1) A radioactive form is even used as a form of cancer treatment for bone cancers andprostate cancer. are clickable links to these studies. I have been treated with bisphosphanates, forteo, prolia and I had 11 non-traumatic spontaneous vertebral compression fractures during treatment. Have you ever heard of strontium? Antacids are used to decrease stomach acid. It's derived from rock calcium bound with citric acid (think citrus juices, especially lime and lemon). The effect of fluoride and strontium application on dentin: in vivo and in vitro studies. Strontium ranelate for preventing and treating postmenopausal osteoporosis. 2009;41(7):559-562. To avoid this interaction, take strontium at least 2 hours before or after taking quinolones. 2003;14 Suppl 3:S56-S65. View abstract. View abstract. View abstract. J Clin.Dent. In the human body, approximately 99 percent of Sr is located in the bones. A., Johansson, H., Oden, A., and McCloskey, E. V. A meta-analysis of the effect of strontium ranelate on the risk of vertebral and non-vertebral fracture in postmenopausal osteoporosis and the interaction with FRAX((R)). Rachitogenic activity of dietary strontium. Physio Flex Pro - Editor's Choice. Strontium ranelate is comprised of 27.8% strontium and 72.2% ranelic acid. Accessed May 1, 2018. Boron may be suitable for arthritis when taken in appropriate amounts. Cochrane Musculoskeletal Group. 2012;23(3):1115-1122. doi: 10.1007/s00198-011-1847-z. [No authors listed]. Am J Med. 1987;66(10):1518-1522. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. J Bone Miner Res 2008;23(S80). View abstract. Eur Urol 2003;44:519-26. Oosterhof GO, Roberts JT, de Reijke TM, et al. Toxicological profile for strontium. All rights reserved. View abstract. 1967;5(6):318-321. These forms are different from the ranelate compound and there have been no studies showing that they are safe or effective. Note that the numbers in parentheses (1, 2, etc.) No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. View abstract. View abstract. Cochrane.Database.Syst.Rev. Kanapka, J. You also do not know whether they can seriously harm you. Dent.Clin.North Am. View abstract. The compound Strontium Citrate has CAS number 40182-75- and molecular formula C6H5O7Sr-. Calcium Citrate. View abstract. A 2007 study only involved six participants, but the researchers found thatregular toothbrushing with a strontium-supplemented toothpaste has been found to increase the strontium content in the exposed enamel, which can be an advantage in the prevention of cariogenesis. (15) What is cariogenesis? Strontium citrate and strontium chloride are supplements and are not tested or regulated by the Food and Drug Administrations (FDA). Estrogens might decrease how fast the body gets rid of strontium. Mayo docs say it will stay in my system for up to three years. Scientific studies have shown that Sr may have positive effects on bone diseases like osteoporosis, bone cancer, prostate cancer, tooth sensitivity and tooth decay. Kidney Int 1999;56:1886-92. 2013 Sep 4;93(5):520-6. doi: 10.2340/00015555-1564. Eur.J.Endocrinol. Its been interesting what research has shown to date aboutits use for osteoporosis. (23), In general, taking very high doses of a Sr supplement is typically not considered safe and taking too much could even damage bones, so be careful when taking strontium, as recommended by the ATSDR (Agency for Toxic Substances and Disease Registry). Strontium(89) chloride versus palliative local field radiotherapy in patients with hormonal escaped prostate cancer: a phase III study of the European Organisation for Research and Treatment of Cancer, Genitourinary Group. Select a condition to view a list of vitamins. Kidney Int 2003;64:534-43. . Results 12 weeks following cessation of 8 weeks' supervised use. (Accessed 01 August 2006). European Medicines Agency, 2005. Wang, C. T., Lin, J., Chang, C. J., Lin, Y. T., and Hou, S. M. Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. Uchida, A., Wakano, Y., Fukuyama, O., Miki, T., Iwayama, Y., and Okada, H. Controlled clinical evaluation of a 10% strontium chloride dentifrice in treatment of dentin hypersensitivity following periodontal surgery. Bellamy, N., Campbell, J., Robinson, V., Gee, T., Bourne, R., and Wells, G. Viscosupplementation for the treatment of osteoarthritis of the knee. Cheung, K. M., Lu, W. W., Luk, K. D., Wong, C. T., Chan, D., Shen, J. X., Qiu, G. X., Zheng, Z. M., Li, C. H., Liu, S. L., Chan, W. K., and Leong, J. C. Vertebroplasty by use of a strontium-containing bioactive bone cement. Can and should treatments such as these be used in conjunction with strontium citrate, about which I know nothing by the way? View abstract. Fluoride helps protect your teeth from the acid that is released when this happens. Osteoporosis Int. Any feedback to help me through this maze will be highly appreciated. Spector, T. D., Conaghan, P. G., Buckland-Wright, J. C., Garnero, P., Cline, G. A., Beary, J. F., Valent, D. J., and Meyer, J. M. Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]. Modawal, A., Ferrer, M., Choi, H. K., and Castle, J. Minkoff S, Axelrod S. Efficacy of strontium chloride in dental hypersensitivity. View abstract. In osteoporotic women treated with strontium ranelate, strontium is located in bone formed during treatment with a maintained degree of mineralization. Strontium results in an overestimation (up to 50%) of the increase in bone density using DXA methods.[3]. Aluminum, iron, lead, cadmium, copper, zinc, chromium, magnesium, strontium, and calcium content in bone of end-stage renal failure patients. Seafood is a top source of Sr, but it can also be found in smaller quantities in whole milk, grains,beans, spinach, lettuce, celery, androot vegetableslike carrots and potatoes. A 2016 systematic review published in European Urology took a look at several radiopharmaceuticals including Sr-89 for reducing the malignant bone pain from prostate cancer. It does not recommend it as a treatment for anyonewho has or has had heart or circulatory problems such as stroke, heart attack, or obstruction of the blood flow in the arteries. Oral Dis. 2006;21(4):536-542. 2009;20(10):1663-1673. Proc.R.Soc.Lond B Biol.Sci. Thromb.Haemost. Basically, it is like you are consuming rocks. The effect of prior bisphosphonate therapy on the subsequent therapeutic effects of strontium ranelate over 2 years. This decreases the amount of tetracyclines that can be absorbed. Ngo, H. C., Mount, G., Mc, Intyre J., Tuisuva, J., and Von Doussa, R. J. The typical diet includes 0.5 to 1.5 milligrams of strontium each day. View abstract. CMAJ. Some research shows that giving a special prescription form of strontium (strontium-89 chloride) intravenously (by IV) slows the growth of prostate cancer that is resistant to treatment and also relieves pain. Roux, C., Fechtenbaum, J., Kolta, S., Briot, K., and Girard, M. Mild prevalent and incident vertebral fractures are risk factors for new fractures. View abstract. I did find some information on the Mayo Clinic website on osteoporosis. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. Health Phys 2004;86:193-6. Dermatology 2000;200(3):244-246. The efficacy of glucosamine sulfate in osteoarthritis: financial and nonfinancial conflict of interest. 2003. Founded in 1999, ConsumerLab.com is a leading provider of consumer information and independent evaluations of products that affect health and nutrition. Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis. Do not be misled by marketing materials that compare them to strontium ranelate. Some male hormones include testosterone, nandrolone, oxandrolone, and oxymetholone. Arrich, J., Piribauer, F., Mad, P., Schmid, D., Klaushofer, K., and Mullner, M. Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis. JAMA 8-18-1999;282(7):637-645. JAMA 12-23-1998;280(24):2077-2082. 2008;67(12):1736-1738. Reginster, J. Y., Lecart, M. P., Deroisy, R., and Lousberg, C. Strontium ranelate: a new paradigm in the treatment of osteoporosis. View abstract. View abstract. If you want to take a strontium supplement, it is recommended to ask your doctor first. View abstract. JAMA 1995;274:420-4. A., Mohr, D. N., Petterson, T. M., O'Fallon, W. M., and Melton, L. J., III. Connect with thousands of patients and caregivers for support and answers. The body needs zinc for the immune system to work properly. J.Clin.Endocrinol.Metab 2007;92(8):3076-3081. What else is it good for? The possible risks of strontium warrant more long-term independent studies.